Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

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The catalytic mechanism of Cdc25A phosphatase.

Cdc25 phosphatases are dual specificity phosphatases that dephosphorylate and activate cyclin-dependent kinases (CDKs), thereby effecting the progression from one phase of the cell cycle to the next. Despite its central role in the cell cycle, relatively little is known about the catalytic mechanism of Cdc25. In order to provide insights into the catalytic mechanism of Cdc25, we have performed ...

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ژورنال

عنوان ژورنال: Oncogene

سال: 2004

ISSN: 0950-9232,1476-5594

DOI: 10.1038/sj.onc.1207394